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What is menopause?
The period preceding final cessation of menstruation, perimenopause, is characterized by significant changes in oestrogen levels that can lead to a variety of symptoms of differing intensity. It is during this transition period that menstrual irregularities and uncomfortable symptoms appear: flushing, sleep disturbance, mood swings, etc. Some women are unaffected or suffer very little, while for others it can be years of misery.
In addition, as oestrogen levels drop during menopause, there is an increased risk of cardiovascular disorders. Heart disease and circulatory system problems rise dramatically among postmenopausal women.
This is why we designed Annedda MENOPAUSE®, a product specially formulated to relieve the symptoms associated with menopause and reduce the risk of suffering from cardiovascular disorders.
Counteracts the symptoms of menopause
Black cohosh
The roots of black cohosh have long been used by the native peoples of North America for relieving pain associated with the female reproductive system. In the mid-20th century, German doctors began to use a standardized black cohosh extract as an alternative to hormone replacement in postmenopausal women. More recently, reviews of clinical trials have concluded that black cohosh is effective at alleviating the hot flashes and mood disorders that can occur with menopause.1
Vitex (chaste tree)
Clinical trials have shown that the small fruit of Vitex, which resembles a peppercorn, can effectively alleviate irritability and mood disorders related to hormonal changes in women with premenstrual syndrome2 and symptoms associated with perimenopause.
Maca
The roots of maca, a Peruvian plant, have shown to have a positive effect on the quality of life of women in early menopause. This includes mitigating some psychological symptoms such as anxiety, depression and sexual dysfunction.3
Reduces cardiovascular risks
White pine bark
White pine bark extract standardized to 95% proanthocyanidins offers many benefits for patients with or at risk of cardiovascular disorders. Thanks to its exceptional antioxidant power, anti-inflammatory properties and favourable action on the connective tissues that form the internal walls of blood vessels, it offers many benefits, including: counteracting blood clot formation and thus preventing heart attack and stroke;4 helping control blood pressure;5 protecting vessels when blood cholesterol and triglyceride levels rise;6 ensuring the integrity and proper functioning of blood vessel walls;7 and contributing to the treatment of venous insufficiency.8
This is the Annedda® flagship extract, an exceptional antioxidant and the best in the world in its category.
Turmeric
Turmeric, another natural antioxidant, also has anti-inflammatory properties that effectively protect against heart disease and circulatory system disorders. Researchers have recently shown that the incidence of cardiovascular disorders is related to the presence of chronic inflammation. Unfortunately, the technologies used by major producers of turmeric extract eliminate almost all of turmeric’s natural aromatic constituents (essential oils). This means that the turmeric extracts generally available to consumers are incomplete. We go to great lengths to ensure the essential oil missing from commercial products is added to our product so that you are benefiting from the complete extract. You will notice the difference as soon as you open our product and smell its characteristic aroma.
Other antioxidants
For good measure, we have also added vitamin C and blueberry extract, two other antioxidants that boost the effects of the white pine extract and turmeric.
Composition of annedda menopause®
60 vegetable capsules
Annedda menopause®
NPN 80048214
Medicinal ingredients :
Black cohosh (Actaea racemosa), roots and rhizomes100 mg
Vitex (Vitex agnus-castus), fruit100 mg
Turmeric (Curcuma longa), rhizome, 30:1 extract (equivalent to 3000 mg of dried root)100 mg
White pine (Pinus strobus) bark extract standardized to 95% proanthocyanidins100 mg
Maca (Lepidium meyenii), root, 4:1 extract (equivalent to 200 mg of dried root)50 mg
Vitamin C50 mg
Non-medicinal ingredients:
Blueberry extract, piperine, vegetable magnesium stearate, monoglycerides, hypromellose (vegetable capsule).
Dosage (adults) :
Take 1 capsule 2 times daily, 1 hour before or 2 hours after a meal.
Indications: :
- Utilisé en phytothérapie pour aider à soulager les symptômes reliés à la ménopause.
- Fournit des antioxydants pour le maintien d’une bonne santé.
Warnings:
Consult a health care practitioner before use if: you have gallstones or bile duct obstruction; you suffer from stomach ulcers or excess stomach acid; you suffer from liver problems or if liver problem symptoms occur; use extends beyond 3 months; symptoms persist or worsen. Keep out of reach of children. Do not use if the safety seal under the cap is broken or missing.
Contraindications:
Do not use if you are pregnant or breastfeeding. Do not use after a transplant.
1- Mahady GB. Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. Treat Endocrinol. 2005;4(3):177-84. Review. Carroll DG. Nonhormonal therapies for hot flashes in menopause. Am Fam Physician. 2006 Feb 1;73(3):457-64. Review. Full text: www.aafp.org Geller SE, Studee L. Contemporary alternatives to plant estrogens for menopause. Maturitas. 2006 Nov 1;55 Suppl 1:S3-13. Review. Full text: www.pubmedcentral.nih.gov 22. Cheema D, Coomarasamy A, El-Toukhy T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidencebased review. Arch Gynecol Obstet. 2007 Nov;276(5):463-9. Review.
2- He Z, Chen R, et al. Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China. Maturitas. 2009 May 20;63(1):99-103. Ma L, Lin S, et al. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecol Endocrinol. 2010 Aug;26(8):612-6. Ma L, Lin S, et al. Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Aust N Z J Obstet Gynaecol. 2010 Apr;50(2):189-93.
3- Meissner HO, Mscisz A, Reich-Bilinska H, et al. Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (II) Physiological and Symptomatic Responses of Early-Postmenopausal Women to Standardized doses of Maca in Double Blind, Randomized, Placebo-Controlled, Multi-Centre Clinical Study. Int J Biomed Sci. Dec 2006; 2(4): 360–374. Brooks NA, Wilcox G, Walker KZ, et al. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause. 2008 Nov-Dec;15(6):1157-62.
4- Araghi-Niknam M, Hosseini S, Larson D, et al. Pine bark extract reduces platelet aggregation. Integr Med. 2000 Mar 21;2(2):73-77. Pütter M, Grotemeyer KH, Würthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res. 1999 Aug 15;95(4):155-61.
5-Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol. 1998 Oct;32(4):509-15. Liu X, Wei J, Tan F, et al. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62.
6- da Silva Porto PA, Laranjinha JA, de Freitas VA. Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships. Biochem Pharmacol. 2003 Sep 15;66(6):947-54. Devaraj S, Vega-López S, Kaul N, et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids. 2002 Oct;37(10):931-4.
7- Liu F, Lau BH, Peng Q, Shah V. Pycnogenol protects vascular endothelial cells from beta-amyloid-induced injury. Biol Pharm Bull. 2000 Jun;23(6):735-7. Peng Q, Wei Z, Lau BH. Pycnogenol inhibits tumor necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells. Cell Mol Life Sci. 2000 May;57(5):834-41. Virgili F, Kim D, Packer L. Procyanidins extracted from pine bark protect alpha-tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite. FEBS Lett. 1998 Jul 24;431(3):315-8. Belcaro G, Cesarone MR, Ricci A, et al. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin- converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4.
8- Gulati OP. Pycnogenol® in Chronic Venous Insufficiency and Related Venous Disorders. Phytother Res. 2013 Jun 15. doi: 10.1002/ptr.5019. Belcaro G, Cesarone MR, Rohdewald P, et al. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004 Oct;10(4):373-7. Petrassi C, Mastromarino A, Spartera C. PYCNOGENOL in chronic venous insufficiency. Phytomedicine. 2000 Oct;7(5):383-8. Daróczy J, Pál A, Blaskó G. [Microcirculatory changes in patients with chronic venous and lymphatic insufficiency and heavy leg symptoms before and after therapy with procyanidol oligomers (laser-Doppler study)]. [Article in Hungarian, summary in English]. Orv Hetil. 2004 May 30;145(22):1177-81.
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